NEUROMEDIN U (RAT)

Name	NEUROMEDIN U (RAT)
Synonyms	NMU, RAT neuromedin U NMU-23 (RAT) neuromedin U-23 NEUROMEDIN U (RAT) YKVNEYQGPVAPSGGFFLFRPRN-NH2 TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2 H-TYR-LYS-VAL-ASN-GLU-TYR-GLN-GLY-PRO-VAL-ALA-PRO-SER-GLY-GLY-PHE-PHE-LEU-PHE-ARG-PRO-ARG-ASN-NH2
CAS	117505-80-3

Molecular Formula	C124H180N34O31
Molar Mass	2642.97
Appearance	lyophilized powder
Storage Condition	−20°C
In vitro study	To establish an electrochemiluminescent (ECL) binding assay for NMUR2 receptor, the peptide Neuromedin U (NMU-23) is labeled at the N terminus with Ru(bpy) 2+ 3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy) 2+ 3 -ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy) 2+ 3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash, homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection. Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy) 2+ 3 -NMU-23 to human NMUR2 receptors. From competition binding experiments, the K i values for NMU-23 is determined to be 4.7 nM.

Safety Description	S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes.
WGK Germany	3

biological activity	Neuromedin U, rat is a brain-gut peptide containing 23 amino acids,, NMUR2 regulates several important physiological functions including energy balance, stress response and nociception through its cognate receptor in the central nervous system.
Target	NMUR2
in vitro study	To establish is labeled at the N terminus with Ru(bpy) 2 3 and allowed to bind to the human NMUR2 receptor in the cell membranes immobilized on the electrode on the bottom of each assay plate. Upon application of an electric current, the receptor-bound Ru(bpy) 2 3 -ligand undergoes an oxidation-reduction cycle in the presence of a coreactant tripropylamine and emits light. Signal is only generated when the Ru(bpy) 2 3 label is in proximity to the electrode, thus discriminating the bound label from the unbound and enabling a no wash homogenous assay format. The ECL-based NMUR2 binding assay is used to screen our corporate compound collection. Approximately 670,000 compounds with diverse structures are tested at 10 μM for their ability to displace the binding of 0.5 nM Ru(bpy) 2 3 -NMU-23 to human NMUR2 receptors. From competition binding experiments, the K I values for NMU-23 is determined to be 4.7 nM.

Last Update：2024-04-09 20:49:11

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Product Name: NEUROMEDIN U (RAT) Visit Supplier Webpage Request for quotation
CAS: 117505-80-3
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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NEUROMEDIN U (RAT)

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